Platelet-Leucocyte Conjugates
Activated platelets may adhere to leukocytes and form circulating mixed aggregates, platelet-leucocyte conjugates. The latter are considered a reliable marker of prothrombotic conditions and provide a link between inflammation and thrombosis, two central processes in atherogenesis.
Our scientists have well established flow cytometric techniques to measure platelet-leucocyte interactions in fixed whole blood samples.
The assay can also be performed using a 96-well plate format in combination with whole blood aggregation and, therefore, can offer measurement of platelet-leucocyte conjugates in small volumes of whole blood providing the benefit of multiple sample testing.
Publications
A new approach to measuring platelet aggregation and platelet-leucocyte conjugate formation in a small volume of fixed whole blood.
http://onlinelibrary.wiley.com/doi/10.1111/jth.12993/epdf – page 655
The effects of GPIIb-IIIa antagonists and a combination of three other antiplatelet agents on platelet-leukocyte interactions. Current Medical Research and Opinion, 19(3): 178-186.
Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro. British Journal of Pharmacology, 134(2): 353-358.