Platelet-Leucocyte Conjugates

Platelet-Leucocyte Conjugates

Activated platelets may adhere to leukocytes and form circulating mixed aggregates, platelet-leucocyte conjugates. The latter are considered a reliable marker of prothrombotic conditions and provide a link between inflammation and thrombosis, two central processes in atherogenesis.

Our scientists have well established flow cytometric techniques to measure platelet-leucocyte interactions in fixed whole blood samples.

The assay can also be performed using a 96-well plate format in combination with whole blood aggregation and, therefore, can offer measurement of platelet-leucocyte conjugates in small volumes of whole blood providing the benefit of multiple sample testing.

Publications

A new approach to measuring platelet aggregation and platelet-leucocyte conjugate formation in a small volume of fixed whole blood. 

http://onlinelibrary.wiley.com/doi/10.1111/jth.12993/epdf – page 655

The effects of GPIIb-IIIa antagonists and a combination of three other antiplatelet agents on platelet-leukocyte interactions. Current Medical Research and Opinion, 19(3): 178-186. 

DOI: 10.1185/030079903125001721

Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro.  British Journal of Pharmacology, 134(2): 353-358.

DOI: 10.1038/sj.bjp.0704248

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